Mouse Anti-Human VEGF-B

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Cat-Nr.101-M62
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7B43)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with human VEGF-B167 recombinant protein). The IgG1 fraction of culture supernatant was purified by Protein G affinity chromatography.
Antigenrecombinant human VEGF-B 167
ApplicationWB, IHC (P)
Synonymsvascular endothelial growth factor B; VEGFB; VRF; VEGFL
DescriptionVEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.
Uniprot IDP49765
Protein RefSeqNP_003368.1
mRNA RefSeqNM_003377.4

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