Rat Anti-Mouse VEGFR-2/KDR, Antagonistic

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Cat-Nr.mV1001.1r-m
Size200 µg
Price390 €
CategoryMonoclonal Antibody
Clone Nr.(#MAB0701)
IsotypeIgG1
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with purified mouse VEGFR2 extracellular domain
Antigenmouse VEGFR2 extracellular domain
ApplicationWB, Attenuation of VEGF-induced KDR tyrosine phosphorylation, IP
Synonymsvascular endothelial growth factor receptor-2 ; Kdr; Ly73; Flk-1; VEGFR2; VEGF receptor 2; kinase insert domain protein receptor
DescriptionVEGF R1 (Flt-1), VEGF R2 (KDR/Flk-1), and VEGF R3 (Flt-4) belong to the class III subfamily of receptor tyrosine kinases (RTKs). All three receptors contain seven immunoglobulin-like repeats in their extracellular domain and kinase insert domains in their intracellular region. They are best known for regulating VEGF family-mediated vasculogenesis, angiogenesis, and lymphangiogenesis. They are also mediators of neurotrophic activity and regulators of hematopoietic development. Human VEGF R2 is thought to be the primary inducer of VEGF-mediated blood vessel growth, while VEGF R3 plays a significant role in VEGF-C and VEGF-D-mediated lymphangiogenesis. The antibody will bind near the ligand binding site of the receptor and has antagonistic activity by blocking the binding of natural ligands.
Uniprot IDP35918
Protein RefSeqACJ66293.1
mRNA RefSeqEU884114

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