Mouse Anti-Human NRP-2

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Cat-Nr.101-M197
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#29H31)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageThe lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
AntigenRecombinant Human Neuropilin-2
ApplicationWB
SynonymsNRP-2, Vascular endothelial cell growth factor 165 receptor 2, VEGF165R2
DescriptionNeuropilin receptor 2 (NRP-2) is a 120 kDa, type I transmembrane (TM) glycoprotein that is related to the semaphorin receptor family. NRP-2 is a complex molecule with multiple splice forms. Five transmembrane forms are known, and one 62 kDa soluble form has been identified. Based on the originally reported precursor size of 909 amino acids (aa), the “Standard ” precursor in human will have a 20 aa signal sequence, an 842 aa extracellular region, a 25 aa TM segment, and a 42 aa cytoplasmic tail. The extracellular region contains two N terminal CUB domains, two jellyroll shaped coagulation factor V type C domains, and a juxtamembrane MAM domain. The CUB and factor V domain are involved in VEGF and semaphorin binding. The MAM domain appears necessary for signaling through Plexin. The five transmembrane isoforms all share the same CUB, factor V and MAM domains. Two of the four variants show a complete replacement of these 101 aa with a totally unrelated stretch of approximately 90 aa. This creates a new TM and cytoplasmic tail. These forms are called “NRP 2b” forms. Two other isoforms (plus the standard 909 aa form) retain the 101 aa stretch, and add either 17 or 22 aa to the end of the extracellular region. These forms are called “NRP 2a” forms. The soluble form of NRP 2 is 555 aa in precursor length, and contains the two CUB domains plus the first 1½ factor V type C domains. NRP 2 binds Sema3B through F, and VEGF isoforms 165, 145, PlGF-2 and VEGF-C. It is known to form homodimers and heterodimers with NRP 1, and it forms receptor complexes with Plexin 1 and VEGFR-1. NRP 2 is found on a variety of cell types including neurons, vascular endothelial cells, Schwann cells and pancreatic acinar cells.
Uniprot IDO60462-6
Protein RefSeqNP_003863.2
mRNA RefSeqNM_003872.2

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