Mouse Anti-Human NGF-beta

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Cat-Nr.101-M582
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#12A29)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of b-NGF.
Antigenrecombinant human NGF-beta
ApplicationELISA, N
SynonymsKLRC1; NKG2; NKG2A; CD159A
Descriptionβ-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human β-NGF is a noncovalently disulfide-linked homodimer, of two 14 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.
Uniprot IDP01138
Protein RefSeqNP_002497.2
mRNA RefSeqNM_002506

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