Rat Anti-Mouse Toll-like Receptor 2 (TLR2)

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Cat-Nr.103-M278
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#5B57)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with purified mouse recombinant TLR2 extracellular domain. The IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Antigenmouse recombinant protein of the EC-domain of TLR2
ApplicationWB
SynonymsTlr2; Ly105
DescriptionTLRs make up a family of pattern recognition receptors that play important roles in the innate immune response. Broad classes of pathogens (e.g. viruses, bacteria, and fungi) constitutively express a set of mutation-resistant molecules called pathogen-associated molecular patterns (PAMPs). These microbial molecular markers may be composed of proteins, carbohydrates, lipids, nucleic acids and/or combinations thereof. Individual TLRs recognize distinct pathogen-associated PAMPs, initiating signaling cascades that promote the immune response. Structurally, TLRs are type I transmembrane receptors that possess varying numbers of extracellular N-terminal leucine-rich repeat (LRR) motifs, followed by a cysteine-rich region, a TM domain, and an intracellular Toll/IL-1 R (TIR) motif. The TIR motif is common to the larger IL-1 R/TLR superfamily.
Uniprot IDQ9QUN7
Protein RefSeqNP_036035.3
mRNA RefSeqNM_011905.3

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