Mouse Anti-Human TIMP-3

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Cat-Nr.101-M125
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7D3)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified recombinant human tissue inhibitor of metalloproteinases-3 (TIMP-3. The IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigenhuman recombinant TIMP-3 protein
ApplicationWB, IHC (P)
SynonymsTIMP3; SFD; K222; K222TA2; HSMRK222
DescriptionTIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.
Uniprot IDP35625
Protein RefSeqNP_000353
mRNA RefSeqNM_000362

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