Mouse Anti-Human Thrombopoietin R

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Cat-Nr.101-M645
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#1Z3)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of TpoR extracellular domain.
ApplicationWB
SynonymsMPL; MPLV; TPOR; C-MPL; CD110; THCYT2
DescriptionThrombopoietin receptor (Tpo R), also known as myeloproliferative leukemia protein (c-Mpl), is a type I transmembrane protein that is a member of the hematopoietin/cytokine receptor superfamily. As a consequence of alternative splicing, there are four identified mRNA variants. The functional receptor is encoded by the P isoform of mRNA. The human and mouse receptors share approximately 81% amino acid sequence identity. Tpo R is expressed at low levels in various cell types, including hematopoietic progenitor cells, megakaryocytes and platelets.
Uniprot IDP40238
Protein RefSeqNP_005364.1
mRNA RefSeqNM_005373.2

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