Rat Anti-Mouse Semaphorin 7A

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Cat-Nr.103-M466
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#4G28)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Semaphorin 7A.
Antigenrecombinant mouse Semaphorin 7A
ApplicationWB
SynonymsSema7a; Semal; CDw108; H-Sema-L; M-Sema-L; 2900057C09Rik
DescriptionThe Semaphorins make up the largest family of axon guidance cues yet described. Semaphorins are divided into 8 classes (classes 3-7 found in vertebrates). Class 3 Semaphorins are secreted, classes 4 through 6 are transmembrane proteins, and class 7 are membrane associated via glycosylphosphatidylinositol (GPI) linkage. They are characterized structurally by a conserved ~400 amino acid sema domain. They are classically described as collapsing factors and mediators of axon repulsion, although they may also act as context-dependent chemoattractants. Semaphorins have been shown to have roles in cardiovascular development and in the regulation of immune cell antigen presentation. Receptors or receptor complexes that mediate semaphorin signaling include proteins of the Neuropilin and Plexin families.
Uniprot IDQ9QUR8
Protein RefSeqNP_035482.1
mRNA RefSeqNM_011352.2

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