Mouse Anti-Human TFPI-2

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Cat-Nr.101-M644
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#1Z3)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with the recombinant human TFPI-2.
Antigenrecombinant human TFPI-2
ApplicationWB
SynonymsTFPI2; PP5; REF1; TFPI-2
DescriptionHuman TFPI is a physiological inhibitor of the extrinsic pathway of coagulation and functions in anticoagulation and anti-inflammation. It is a secreted protein with an N-terminal acidic region, three Kunitz (K) domains separated by two linker regions, and a C-terminal basic region. The first K domain inhibits coagulation factor VIIa complexed to tissue factor (TF). The second K domain inhibits factor Xa. The third K domain binds to heparin. The C-terminal basic region may have several functions. Human TFPI-2 is structurally similar to TFPI and is downregulated in several cancers.
Uniprot IDP483078
Protein RefSeqNP_006519.1
mRNA RefSeqNM_006528.3

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