Mouse Anti-Human TIE-1

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Cat-Nr.101-M47
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#12D9)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human extracellular domain of TIE-1 fragment). The IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigenhuman Tie1 extracellular domain
ApplicationWB, IHC
SynonymsTIE1; TIE; JTK14
DescriptionTie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). It is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2.
Uniprot IDP35590
Protein RefSeqNP_005415
mRNA RefSeqNM_005424

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