Mouse Anti-Human TIE-1

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Cat-Nr.101-M48
Size100 µg
Price230 €
CategoryMonoclonal Antibody
Clone Nr.(#6F12)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionCentrifuge vial prior to opening. Reconstitute in sterile water to a concentration of 1.0 mg/ml.
Stability and StorageThe lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C.
PreparationThe monoclonal antibody was produced with the help of BALB/c mice using recombinant human soluble extracellular TIE-1 as the immunizing antigen. Mouse IgG1 antibody (#6F12) from hybridomas was purified from cell culture supernatant by Protein G chromatography.
Antigenrecombinant human soluble TIE-2
ApplicationELISA, WB, FC
SynonymsTIE1; TIE; JTK14
DescriptionTie-1/Tie and Tie-2/Tek are receptor tyrosine kinases with unique structural characteristics including two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains, followed by three fibronectin type III-like repeats in the extracellular region, and a split tyrosine kinase domain in the cytoplasmic region. Tie-2 is a receptor for the angiopoietin (ANG) family: ANG-1, ANG-2, and ANG-3 (mouse)/-4 (human). It is involved in vascular stabilization and remodeling. Although less well understood, Tie-1 may also act as an ANG receptor, possibly in complex with Tie-2.
Uniprot IDP35590
Protein RefSeqNP_005415
mRNA RefSeqNM_005424

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