Rat Anti-Mouse LPAM-1

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Cat-Nr.103-M176
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#2G18)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with cell lysates of mouse lymphocytes. IgG2 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
Antigencell lysates of mouse lymphocytes
ApplicationIHC (P), FC, IP
SynonymsLPAM-1
DescriptionThe antibody is specific for a combinatorial determinate of integrin α4β7complex. Integrin α4β7 is composed of a 150 kD (α4 or CD49d) and a 130 kD (β7) heterodimer, also known as CD49d/β7 or LPAM-1. Belonging to the Ig superfamily, it is found on the majority of peripheral lymphocytes and subsets of thymocytes and bone marrow cells (including mast cell progenitors). Integrin α4β7 binds its ligands, VCAM-1 (CD106), MAdCAM-1 and fibronectin, and plays an important role in lymphocytes adhesion and the direction of migration of blood lymphocytes to the intestine and associated lymphoid tissues.
Uniprot IDP26011
Protein RefSeqNP_038594.2
mRNA RefSeqNM_013566.2

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