Mouse Anti-Human LAG-3

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Cat-Nr.101-M544
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#3C39)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of LAG-3 (also called CD223).
Antigenrecombinant human LAG-3
ApplicationWB
SynonymsLAG3; CD223
DescriptionLAG-3 (Lymphocyte activation gene-3), also known as CD223, is a member of the immunoglobulin superfamily (IgSF). The mature LAG-3 protein is a 496 amino acid (aa) membrane protein with a 421 aa extracellular region that contains four IgSF domains, a 21 aa transmembrane region and a 54 aa cytoplasmic region. LAG-3 and CD4 molecules share < 20% aa sequence homology but have a similar structure. Both molecules bind to MHC class II. LAG-3 binds to MHC class II with higher affinity than CD4. Both LAG-3 and CD4 genes are located on the distal part of the short arm of chromosome 12.
Uniprot IDP18627
Protein RefSeqNP_002277.4
mRNA RefSeqNM_002286.5

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