Rat Anti-Mouse Interferon alpha/beta R2

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Cat-Nr.103-M400
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#5L16)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of INFa/b R2 extracellular domain
Antigenrecombinant mouse protein of INF alpha/beta R2
ApplicationWB, IHC
SynonymsIfnar2; Ifnar-2; AI74730 ; Interferon receptor
DescriptionIFN-alpha/beta R2, also known as IFNAR2, is a 100 kDa component of the class II cytokine receptor that binds the type I interferons IFN-alpha, IFN-beta, and IFN-omega. IFN-alpha/beta R2 associates with the 125 kDa IFN-alpha/beta R1 component to form a receptor complex that transmits antiviral and antiproliferative signals. Down-regulation of the receptor is accomplished by ubiquitination and degradation. A soluble form of the protein, corresponding to the extracellular ligand-binding domain, is generated by alternative splicing.
Uniprot IDP48551
Protein RefSeqNP_000865.2
mRNA RefSeqNM_000874.3

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