Mouse Anti-Human TNFRSF11B

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Cat-Nr.101-M655
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#7D37)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human TNFRSF11B, also called Osteoprotegerin.
Antigen recombinant human TNFRSF11B
ApplicationWB, N
SynonymsTNFRSF11B; OPG; TR1; OCIF
DescriptionOsteoprotegerin (OPG)/osteoclastogenesis inhibitory factor (OCIF) is a member of the TNF receptor superfamily and is now referred to as TNFRSF11B. It is an osteoblast secreted decoy receptor that binds specifically to osteoprotegrin ligand (OPGL/TNFSF11) to inhibit osteoblast maturation. It is also a decoy receptor for TRAIL and inhibits TRAIL-induced apoptosis. Human and mouse OPG share approximately 84% and 94% amino acid sequence identity, respectively, with rat OPG. Natural OPG exists predominantly as disulfide-linked dimers.
Uniprot IDO00300
Protein RefSeqNP_002537.3
mRNA RefSeqNM_002546.3

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