Rat Anti-Mouse Siglec-E

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Cat-Nr.103-M69
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#17E34)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
AntigenMouse Siglec-E
ApplicationFC
SynonymsSialic acid-binding Ig-like lectin 12, Siglec-12, Myeloid inhibitory siglec, MIS, Sialic acid-binding Ig-like lectin 5, Siglec-5, Sialic acid-binding Ig-like lectin E, Siglec-E, Sialic acid-binding Ig-like lectin-like 1, Siglec-L1, Siglece, Siglecl1
DescriptionSiglecs are I-type (Ig-type) lectins belonging to the Ig superfamily. They are characterized by an N-terminal, Ig-like V-type domain that mediates sialic acid binding, followed by varying numbers of Ig-like C2-type domains (2 to 17), a single transmembrane region, and a cytoplasmic tail. The siglecs can be broadly classified into two subgroups: siglecs-1, -2, and -4, and a siglec-3/CD33-related subgroup (siglecs-3, and -5 through -13 in primates) defined by sequence similarity and clustered gene localization. They are widely expressed on hematopoietic cells, often in a cell-type-specific manner, and siglec-4/MAG is a myelin component in Schwann cells and oligodendrocytes. Their ligands, sialic acids, are negatively charged monosaccharides found on cell-surface glycoproteins and glycolipids. Although siglec functions continue to be defined, most have intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM), implicating them in the suppression of immunoreceptor signaling. They may also participate in cell/cell interactions or act as receptors for the entry of viral or bacterial pathogens.
Uniprot IDQ91Y57
Protein RefSeqNP_112458.2.
mRNA RefSeqNM_031181.2

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