Rat Anti-Mouse Ras

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Cat-Nr.103-M458
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#5M52)
IsotypeIgG2
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with mouse recombinant protein of Ras.
Antigenrecombinant mouse Ras
ApplicationWB
SynonymsRas
DescriptionThe Ras proteins (HRas, NRas, and two splice variants of KRas) define a closely related family of 21 kDa GTPases that cycle between GTPbound active and GDP-bound inactive states at the cytoplasmic face of the plasma membrane. Receptor tyrosine kinases and G-protein coupled receptors activate Ras, and effectors include Raf and PI-3-kinase. Activating mutations of Ras, which impair GTPase activity and stabilize the active state, are found in nearly one-third of all human cancers.
Uniprot IDP32883
Protein RefSeqNP_067259.4
mRNA RefSeqNM_02184.6

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