Mouse Anti-Human MMP-13

Slide this table

Cat-Nr.101-M115
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#12E10)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse immunized with purified human recombinant human MMP-13). The IgG1 fraction of the tissue culture supernatant was purified by Protein G affinity chromatography.
Antigenrecombinant human MMP-13
ApplicationWB, IHC (P)
SynonymsMMP13; CLG3; MANDP1
DescriptionMatrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP13 (Collagenase-3) has been demonstrated to degrade a range of extracellular matrix proteins, including collagen types I, II, III, IV, IX, X and XIV, gelatin, aggrecan, perlecan and fibronectin. MMP-13 is distinguished from the other human collagenases by its effecient degradation of type II collagen. MMP13 is expressed by fibroblasts, chrondrocytes and squamous epithelial cells. Structurally, MMP-13 may be divided into several distinct domains; a prodomain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a short hinge region and a carboxyl terminal (hemopexinlike) domain.
Uniprot IDP45452
Protein RefSeqNP_002418.1
mRNA RefSeqNM_002427.3

All prices plus VAT + possible delivery charges