Mouse Anti-Human MMP-2

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Cat-Nr.101-M573
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#8B25)
IsotypeIgG2
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with extracellular domain of human recombinant protein of MMP-2.
Antigenrecombinant human MMP-2
ApplicationWB
SynonymsMMP2; CLG4; MONA; CLG4A; TBE-1; MMP-II
DescriptionMatrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP2 (gelatinase A), a type IV collagenase, can degrade a broad range of substrates including type IV, V, VII and X collagens as well as elastin and fibronectin. It is believed to act synergistically with interstitial collagenase (MMP1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP2 has been shown to be associated with many connective tissue cells as well as neutrophils, macrophages and monocytes. Structurally, MMP2 may be divided into several distinct domains: a prodomain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a fibronectin-like domain thought to play a role in substrate targeting; and a carboxyl terminal (hemopexinlike) domain containing 2 N-linked glycosylation sites.
Uniprot IDP08253
Protein RefSeqNP_004521.1
mRNA RefSeqNM_004530

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