Mouse Anti-Human Junctional adhesion molecule C (JAM-C)

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Cat-Nr.101-M526
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#4M35)
IsotypeIgG1
Species ReactivityHuman
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationMonoclonal antibodies were produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with recombinant human JAM-C. This IgG1 antibody was purified from supernatant on a Protein G chromatography column.
Antigenrecombinant human JAM-C
ApplicationWB, N
SynonymsJAM3; JAMC; JAM-C
DescriptionMembers of the junctional adhesion molecule (JAM) family are type I transmembrane glycoproteins of the immunoglobulin (Ig) superfamily that are localized in the tight junctions between endothelial or epithelial cells and appear to be involved in leukocyte transmigration. JAM-A, also known as platelet adhesion molecule 1 (PAM-1) and platelet F11 receptor, contains two V-type Ig-like domains, forms homodimers, and interacts with LFA-1. JAM-B (vasculoendothelial or VE-JAM) and JAM-C each contain two Ig domains (one V-type and one C2-type), a cytoplasmic PDZ-binding motif and a PKC phosphorylation site. JAM-C interacts with MAC-1 and facilitates JAM-B interaction with integrin alpha 4 beta 1.
Uniprot IDQ9BX67
Protein RefSeqNP_116190.3
mRNA RefSeqNM_032801

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