Rat Anti-Mouse VCAM-1

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Cat-Nr.103-M98
Size100 µg
Price250 €
CategoryMonoclonal Antibody
Clone Nr.(#MAB0804)
IsotypeIgG1
Species ReactivityMouse
Formulationlyophilized
BufferPBS
ReconstitutionReconstitute the antibody with 400 µl sterile PBS and the final concentration is 500 µg/ml.
Stability and StorageLyophilized samples are stable for 2 years from date of receipt when stored at -70 °C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
PreparationThis antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with cytokine stimulated mouse endothelial cells). The IgG1 fraction of culture supernatant was purified by Protein A/G affinity chromatography and lyophilized from a 0.2 µm filtered solution in phosphate-buffered saline (PBS).
AntigenCytokine stimulated mouse endothelial cells
ApplicationWB, IHC (P), IP
SynonymsCD106; Vascular Cell Adhesion Protein 1; V-CAM 1;
DescriptionThe antibody reacts with mouse CD106 (Vascular Cell Adhesion Molecule-1, VCAM-1), a 110 kDa transmembrane glycoprotein expressed by myeloid lineage and bone marrow stromal cells. Endothelial cells constitutively express low levels of CD106 and upregulate it upon cytokine stimulation. CD106 binds to integrin alpha4beta1 (VLA-4, CD49d/CD29) and Integrin a4b7 (LPAM-1) and these interactions in the bone marrow and thymus are important for early lymphocyte and myeloid development. Cytokine-mediated upregulation of CD106 on endothelial cells suggests a role for this antigen in the inflammatory response.
Uniprot IDP29533
Protein RefSeqNP_035823.3
mRNA RefSeqNM_011693.3

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