Description / mouse NT-3 protein
NT3 a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
More Information
| Size | 2 µg |
|---|---|
| Source | E. coli |
| Biological Activity | The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures was found to be in the range of 20-50 ng/ml. |
| Purity Confirmation | > 98% by SDS-PAGE & HPLC analyses |
| Length [aa] | 120 |
| Molecular Weight | 13.6 kDa |
| Species Reactivity | Chicken, Cow, Dog, Frog, Hamster, Mouse, Pig, Rat Human, Monkey |
| Formulation | lyophilized |
| Protein Sequence | MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT |
| Synonyms | Ntf3; Nt3; Ntf-3; AI316846; AI835689 |
| Uniprot ID | P20181 |
| Protein RefSeq | NP_032768.1 |
| mRNA RefSeq | NM_008742.3 |