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    Mouse RANKL, soluble NEW

    Host:
    CHO cells
    Size:
    10 µg
    Price:
    € 170
    Formulation:
    lyophilized
    Catalog Number:
    M10-083
    Synonyms:
    soluble Receptor Activator of NF-κB Ligand, TNFSF11, TRANCE (TNF-Related Activation-induced Cytokine), OPGL, ODF (Osteoclast Differentiation Factor), CD254
    Purity Confirmation:
    > 95% by SDS-PAGE & HPLC analyses
    Biological activity:
    Determined by its ability to activate LacZ reporter under control of NF-kappa-B-responsive element in RAW264.7 cells in the absence of any cross-linking. The expected ED50 for this effect is 3.0-20.0 ng/ml.
    Reconstitution:
    Centrifuge the vial prior to opening!
    Protein Sequence:
    FSGAPAMMEG SWLDVAQRGK PEAQPFAHLT INAASIPSGS HKVTLS SWYH DRGWAKISNM TLSNGKLRVN QDGFYYLYAN ICFRHHETSG S VPTDYLQLM VYVVKTSIKI PSSHNLMKGG STKNWSGNSE FHFYSIN VGG FFKLRAGEEI SIQVSNPSLL DPDQDATYFG AFKVQDID
    Description:
    RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic cells. These dendritic cells then stimulate naïve T-cell proliferation in a mixed lymphocyte reaction, promote the survival of RANK + T-cells, and regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells, including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant mouse sRANK Ligand is a 19.8 kDa polypeptide comprising the TNF-homologous region of RANKL (178 amino acid residues).
    NCBI Gene ID:
    21943
    Uniprot:
    O35235
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