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    Human FRP-4, soluble NEW

    Host:
    CHO cells
    Size:
    25 µg
    Price:
    € 170
    Formulation:
    lyophilized
    Catalog Number:
    S01-075
    Synonyms:
    Secreted frizzled-related protein 4, DDC-4 (rat homologue)
    Purity Confirmation:
    > 95% by SDS-PAGE & HPLC analyses
    Biological activity:
    Determined by its ability to decrease alkaline phosphatase activity in CCL-226 cells when treated with 25ng/ml of Murine Wnt-3a.
    Protein Sequence:
    VRGAPCEAVR IPMCRHMPWN ITRMPNHLHH STQENAILAI EQYEEL VDVN CSAVLRFFLC AMYAPICTLE FLHDPIKPCK SVCQRARDDC E PLMKMYNHS WPESLACDEL PVYDRGVCIS PEAIVTDLPE DVKWIDI TPD MMVQERPLDV DCKRLSPDRC KCKKVKPTLA TYLSKNYSYV IH AKIKAVQR SGCNEVTTVV DVKEIFKSSS PIPRTQVPLI TNSSCQCP HI LPHQDVLIMC YEWRSRMMLL ENCLVEKWRD QLSKRSIQWE ERL QEQRRTV QDKKKTAGRT SRSNPPKPKG KPPAPKPASP KKNIKTRSA Q KRTNPKRV
    Description:
    Secreted Frizzled-Related Proteins (sFRPs) are a family of glycosylated Wnt antagonists characterized by a conserved cysteine-rich domain that shares homology with the cysteine-rich, extracellular domain Frizzled proteins use for the binding of Wnt proteins and receptors. Lacking the transmembrane and intracellular domains of the Frizzled proteins, sFRPs function as soluble modulators of the Wnt signaling pathway through the direct binding of Wnt proteins to this cysteine-rich domain, and the resultant inhibition of Wnt receptor binding and signaling capabilities. sFRP-4 is widely distributed in a variety of embryonic and adult tissues where it can function as a circulating antiangiogenic factor, a potent proapoptotic factor, an inhibitor of insulin secretion, and a suppressor of both tumor growth and metastatic potential through disruption of the Wnt signaling pathway. Research has demonstrated the existence of a direct correlation between the downregulation and/or absence of circulating sFRP-4 and the progression of several cancer types, including ovarian, endometrial, prostate and lung. Upregulation of circulating sFRP-4 has been linked to the deterioration of glucose metabolism in the case of type 2 diabetes, as well as the suppression of the keratinocyte hyperproliferation and epidermal hyperlasia that are definitive of psoriasis. CHO cell-derived recombinant human sFRP-4 is a glycoprotein of 328 amino acid residues that contains a cysteine-rich, Frizzled-homologous domain. The calculated molecular weight of CHO cell-derived Recombinant Human sFRP-4 is 37.8 kDa; however, due to glycosylation, the protein migrates at an apparent molecular weight of approximately 55 - 65 kDa by SDS-PAGE analysis under reducing conditions.
    NCBI Gene ID:
    6424
    Uniprot:
    Q6FHJ7
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