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    Human Oncostatin M (196aa) (OSM) NEW

    Host:
    HEK 293 cells
    Size:
    10 µg
    Price:
    € 170
    Formulation:
    lyophilized
    Catalog Number:
    100-162
    Synonyms:
    OSM
    Purity Confirmation:
    >95% by SDS-PAGE and HPLC analyses
    Biological activity:
    Determined by its ability to stimulate the proliferation of human TF-1 cells. The expected ED50 is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
    Protein Sequence:
    AAIGSCSKEY RVLLGQLQKQ TDLMQDTSRL LDPYIRIQGL DVPKLR EHCR ERPGAFPSEE TLRGLGRRGF LQTLNATLGC VLHRLADLEQ R LPKAQDLER SGLNIEDLEK LQMARPNILG LRNNIYCMAQ LLDNSDT AEP TKAGRGASQP PTPTPASDAF QRKLEGCRFL HGYHRFMHSV GR VFSKWGES PNRSRR
    Description:
    Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6,GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. The human OSM gene encodes for a 252 amino acid polypeptide, containing 25 amino acid signal sequence for secretion and a 227 precursor protein. Proteolytic processing of this precursor removes an 18 amino acid C-terminal peptide, and generates the mature OSM form. PeproTech's Recombinant Human Oncostatin M (196 a.a.) is as HEK293 cell-derived, 196 amino-acid length glycoprotein that has a calculated theoretical molecular weight of 22.2 kDa, but migrates at an apparent molecular weight of 32-34kDa by SDS-PAGE analysis under reducing conditions due to glycosylation.
    NCBI Gene ID:
    5008
    Uniprot:
    P13725
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