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    Human IL-12p70 NEW

    Host:
    HEK 293 cells
    Size:
    10 µg
    Price:
    € 170
    Formulation:
    lyophilized
    Catalog Number:
    100-440
    Synonyms:
    Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF
    Purity Confirmation:
    > 98% by SDS-PAGE & HPLC analyses
    Biological activity:
    Determined by its ability to increase IFN-γ production by anti-TCR mAb-stimulated PBMCs.
    Protein Sequence:
    p35 Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKAR QTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLM DPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS p40 Subunit: IWELKKD VYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KT LTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQ KE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDP QGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVM V DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSW EYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS
    Description:
    IL-12 is a potent regulator of cell-mediated immune responses and it induces IFN-γ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+ and CD8+ cells, and induces the development of IFN-γ-producing Th1 cells. Recombinant Human IL-12 p70, derived from HEK293 cells, is a heterodimeric glycoprotein consisting of disulfide-linked p35 and p40 subunits (503 total amino acid residues). The calculated molecular weight of Human IL-12 p70 is 57.2 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of 65-70 kDa based on SDS-PAGE gel, under non-reducing conditions.
    NCBI Gene ID:
    3592
    Uniprot:
    P29460
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