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    Rat Anti-Human Indian Hedgehog

    Size:
    100 µg
    Price:
    € 250
    Formulation:
    Monoclonal Antibody ; lyophilized
    Clone/AB feature:
    (#9L16)
    Isotype:
    IgG2
    Catalog Number:
    101-M720
    Application:
    WB
    Antibody generation:
    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat) immunized with human recombinant Indian Hedgehog N-terminus.
    Antigen:
    Recombinant Human Indian Hedgehog N-Terminus
    Stability:
    Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
    Reconstitution:
    Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
    Description:
    Indian Hedgehog (Ihh), Sonic Hedgehog (Shh), and Desert Hedgehog (Dhh) are important signaling molecules during embryonic development and are highly conserved within and across species. Mouse Ihh cDNA encodes a 411 amino acid (aa) polypeptide with a predicted 27 aa signal peptide. Post-translational processing yields a 19 kDa lipid-modified N-terminal domain that is the signaling molecule. At the cell surface, Ihh activity is mediated by binding the 12-pass transmembrane receptor, Patched (Ptc), and signaling through the 7-pass transmembrane G-protein coupled receptor, Smoothened (Smo).
    NCBI Gene ID:
    3549
    Uniprot:
    Q14623
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