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    Mouse Anti-Human IL-3 receptor alpha

    Size:
    100 µg
    Price:
    € 250
    Formulation:
    Monoclonal Antibody ; lyophilized
    Clone/AB feature:
    (#11A23)
    Isotype:
    IgG1
    Catalog Number:
    101-M719
    Synonyms:
    IL-3 R alpha, IL3ra
    Application:
    IHC, WB, N
    Antibody generation:
    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human recombinant protein of IL-3R alpha extracellular domain. The IgG1 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
    Antigen:
    recombinant human IL-3 receptor alpha extracellular domain
    Stability:
    Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
    Reconstitution:
    Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
    Description:
    Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.
    NCBI Gene ID:
    3563
    Uniprot:
    P26951
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