Monoclonal Antibody ; lyophilized
IL-3 R alpha, IL3ra
IHC, WB, N
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with purified human recombinant protein of IL-3R alpha extracellular domain. The IgG1 fraction of the culture supernatant was purified by Protein A/G affinity chromatography.
recombinant human IL-3 receptor alpha extracellular domain
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Interleukin 3 (IL-3) is a pleiotropic cytokine that can stimulate proliferation and differentiation of pluripotent hematopoietic stem cells as well as various lineage committed progenitors. IL-3 exerts its activity through binding to a specific cell surface receptor known as IL-3 R. IL-3 R is a heterodimeric structure composed of a 70 kDa IL-3 R alpha subunit (CD123 or beta common) and a 120-140 kDa IL-3 R beta subunit (CD131). CD131 also associates with the receptor for Erythropoietin, forming a tissue-protective hetero-receptor complex.
NCBI Gene ID: