Size:
100 µg
Price:
€ 250
Formulation:
Monoclonal Antibody ; lyophilized
Clone/AB feature:
(#6J48)
Isotype:
IgG1
Catalog Number:
101-M275
Synonyms:
CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7
Application:
WB, N
Antibody generation:
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of CCL-7 (also called MCP-3).
Antigen:
recombinant human CCL-7
Stability:
Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
Reconstitution:
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Description:
MCP2 and CCL7 are two monocyte chemotactic proteins produced by human MG63 osteosarcoma cells. Both MCP2 and CCL7 are members of the CC family of chemokines and share 62% and 71% amino acid sequence identity, respectively, with MCP1. CCL7 also shares 58% amino acid identity with MCP2. CCL7 cDNA encodes a 99 amino acid residue precursor protein from which the N-terminal 23 amino acid residues are cleaved to generate the 76 amino acid residue mature CCL7. Mature CCL7 contains a potential N-linked and several possible O-linked glycosylation sites. Similarly to other CC chemokines, all three MCP proteins are monocyte chemoattractants. In addition, the three MCPs can chemoattract activated NK cells as well as CD4+ and CD8+ T lymphocytes. All three cytokines have also been shown to attract eosinophils and induce histamine secretion from basophils.
NCBI Gene ID:
6354
Uniprot:
P80098
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