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    Mouse Anti-Human IL-17F

    Size:
    100 µg
    Price:
    € 250
    Formulation:
    Monoclonal Antibody ; lyophilized
    Clone/AB feature:
    (#8L18)
    Isotype:
    IgG1
    Catalog Number:
    101-M490
    Synonyms:
    IL17F, Cytokine ML-1
    Application:
    N
    Antibody generation:
    This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a mouse) immunized with human recombinant protein of IL-17F.
    Antigen:
    recombinant human IL-17F
    Stability:
    Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20 °C for at least for six months without detectable loss of activity.
    Reconstitution:
    Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
    Description:
    The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
    NCBI Gene ID:
    64806
    Uniprot:
    Q96PD4
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