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    Rabbit Anti-Human ccbe1 NEW

    Size:
    200 µg
    Price:
    € 290
    Formulation:
    Polyclonal Antibody ; lyophilized
    Catalog Number:
    102-PA36
    Synonyms:
    collagen and calcium binding EGF domains 1; KIAA1983
    Application:
    WB, IF
    Antigen:
    Highly pure (>98%) recombinant human ccbe1 (Cys159-Leu251) derived from E. coli.
    Stability:
    The lyophilized antibody is stable at room temperature for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!
    Reconstitution:
    Reconstitute in sterile water to a concentration of 0.1-1.0mg/mL.
    Description:
    The lymphatic system comprises a vascular system separate from the cardiovascular system, essential for immune responses, fluid homeostasis and fat absorption. Lymphatic vessels develop in a complex process termed lymphangiogenesis that involves budding, migration and proliferation of lymphatic endothelial progenitor cells. A few genes, such as FLT4, FOXC2 and SOX18, are known to be critically involved in lymph vessel formation in humans. Lymphedema, lymphangiectasias, mental retardation and unusual facial characteristics define the autosomal recessive Hennekam syndrome. Homozygosity mapping identified a critical chromosomal region containing ccbe1, encoding Collagen and Calcium-Binding EGF-domain-1, a secreted protein which is required for embryonic lymphangiogenesis in zebrafish. ccbe1 is not expressed in endothelial cells of lymph vessels, and it may be a component of the extracellular matrix. In zebrafish, ccbe1 expression was observed along the earliest migra¬tion routes of endothelial cells that sprout from the posterior cardinal vein and migrate circuitously before developing into lymphatic vessels. ccbe1 might therefore be involved in guidance of these migrating cells.
    NCBI Gene ID:
    147372
    Uniprot:
    Q6UXH8
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